Cardiac troponin T (cTnT) TechNotes

The cardiac isoform of TnT is, similarly to cTnI, widely used as a marker of myocardial cell injury. cTnT has the same release kinetics into the bloodstream and the same sensitivity for minor myocardial injury as cTnI. In the blood of acute myocardial infarction (AMI) patients, cTnT is often found in a free form whereas cTnI is mostly found in complex with TnC. In human beings, cardiac troponin T is encoded by the TNNT2 gene. The major isoform found in normal adult human heart tissue (isoform 6 or TnT3) is 287 amino acids long with a calculated molecular weight of 34.6 kDa.

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