PCT is considered to be the main marker of disorders that are accompanied by systemic inflammation and sepsis.
Procalcitonin (PCT) is a small protein that is synthesized by the C-cells in thyroid glands. In cells, PCT is further cleaved into three molecules: N-terminal fragment (N-terminal PCT), calcitonin and katacalcin.
PCT is considered to be the main marker of disorders that are accompanied by systemic inflammation and sepsis. In addition to sepsis and infection, the level of PCT can increase e.g. as a result of surgery, polytrauma, heat shock, burn injuries or cardiogenic shock. Monitoring PCT levels after cardiac surgery or heart transplantation helps to differentiate an acute graft rejection from bacterial or fungal infections.
For the development of PCT immunoassays we offer monoclonal antibodies that are specific to different fragments of the PCT molecule.
HyTest provides high quality PCT products to support your assay development
We now offer one of our anti-calcitonin mAbs also as an in vitro produced product (Cat.# 4C10cc).
Comparative titration of tag-free PCT from HyTest and from supplier A. Results show that there are no differences in immunoreactivities between the two proteins. Immunoreactivity was measured in sandwich ELISA using mAb pair 16B5-42.