Premature rupture of the fetal membranes (PROM) refers to the rupture of the fetal membranes before onset of labor. PROM is suspected in 10% of pregnancies so it is relatively common. PROM can result in preterm delivery, which in turn is associated with high perinatal mortality. In addition, PROM is associated with an increased risk of intra-amniotic infection that may lead to neonatal sepsis. Therefore, it causes a major risk to the mother and the fetus.
IGFBP-1 is an established marker used for diagnosing PROM. Our monoclonal antibodies specific to IGFBP-1 are suitable for designing a sensitive IGFBP-1 immunoassay. They have been tested with amniotic fluid samples. In addition to several antibodies we also offer a partially purified native IGFBP-1 protein.
10 amniotic fluid samples (AF1-AF10) were tested in an in-house TR-FIA-assay using different antibody combinations specific to IGFBP-1. EDTA-plasma samples (NHP1-NHP5) were used as negative controls.