HbA1c and Other Diabetes Markers

Diabetes mellitus is one of the most challenging health problems in the 21st century. It has become one of the leading causes of death in the world. Diabetes causes substantial health costs because of complications often associated with the disease. These complications include coronary artery and peripheral vascular disease, diabetic neuropathy, amputations, renal failure and blindness.

Diabetes mellitus is one of the most challenging health problems in the 21st century


Diabetes mellitus is one of the most challenging health problems in the 21st century. It has become one of the leading causes of death in the world. Diabetes causes substantial health costs because of complications often associated with the disease. These complications include coronary artery and peripheral vascular disease, diabetic neuropathy, amputations, renal failure and blindness.

HyTest offers antibodies and antigens for development of immunoassays for detection of various diabetes markers such as HbA1c, C-peptide and insulin.
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HbA1c          

A number of studies have shown that glycated hemoglobin (HbA1c) concentration provides a better estimate of average hyperglycemia than routine determinations of blood glucose concentration. HbA1c measurement in diagnosis of type 2 diabetes has been recommended by American Diabetes Association, World Health Organization and International Diabetes Federation.


Calibration curve for HbA1c fluoroimmunoassay. Capture antibody: anti-HbA10 (Cat.#4HH0). Detection antibody: anti-HbA1c (cat.# 4HA1). Calibrator: native HbA1c.

Proinsulin, insulin and C-peptide

Assays for proinsulin, insulin and C-peptide are widely used in the monitoring of hypoglycemia, pathogenesis and treatment of diabetes mellitus. Insulin is synthesized in the pancreas from its precursor proinsulin. During this process, proinsulin is proteolytically cleaved into three peptides: A- and B-chain and C-peptide. A- and B-chains are covalently linked by disulfide bonds to form mature insulin.

Analysis of proinsulin synthesis and processing, as well as insulin and C-peptide clearance, are very important for the improved understanding of carbohydrate metabolism abnormalities. Assays for insulin, proinsulin and C-peptide are widely used in the monitoring of hypoglycemia, pathogenesis and treatment of diabetes mellitus.


Diabetes products related technotes

HbA1c TechNotes
Rat C-peptide and insulin Technotes


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