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HyTest has developed Adn antibodies and the properties of these antibodies were evaluated in a study that was published in the Journal of Immunoassay and Immunochemistry 34:2 (2013) and, with the use of these antibodies, assays that detect LMW, HMW or total Adn can be developed. In addition, we also provide purified native Adn that can be used as a calibrator for all of these Adn immunoassays.
As obesity and metabolic syndrome have become global health burdens, there is an increasing need to find biological markers that can help in the management of metabolic syndrome, pre-diabetes and diabetes. Interest in adiponectin (Adn) increased in mid-2000s as a growing number of studies suggested that it could serve as an effective marker that is predictive of glycemic efficacy. Since then, interest in adiponectin has remained high and it appears that adiponectin will slowly find its way into routine laboratory diagnostics.
HyTest has developed Adn antibodies and the properties of these antibodies were evaluated in a study that was published in the Journal of Immunoassay and Immunochemistry 34:2 (2013) and, with the use of these antibodies, assays that detect LMW, HMW or total Adn can be developed. In addition, we also provide purified native Adn that can be used as a calibrator for all of these Adn immunoassays.
For more information and pair recommendations please see the Adiponectin TechNotes under “Literature” tab.
Schematic representation of adiponectin oligomeric forms.
HbA1c. A number of studies have shown that glycated hemoglobin (HbA1c) concentration provides a better estimate of average hyperglycemia than routine determinations of blood glucose concentration. HbA1c measurement in diagnosis of type 2 diabetes has been recommended by American Diabetes Association, World Health Organization and International Diabetes Federation.
Proinsulin, insulin and C-peptide. Assays for proinsulin, insulin and C-peptide are widely used in the monitoring of hypoglycemia, pathogenesis and treatment of diabetes mellitus. Insulin is synthesized in the pancreas from its precursor proinsulin. During this process, proinsulin is proteolytically cleaved into three peptides: A- and B-chain and C-peptide. A- and B-chains are covalently linked by disulfide bonds to form mature insulin.
Analysis of proinsulin synthesis and processing, as well as insulin and C-peptide clearance, are very important for the improved understanding of carbohydrate metabolism abnormalities. Assays for insulin, proinsulin and C-peptide are widely used in the monitoring of hypoglycemia, pathogenesis and treatment of diabetes mellitus.
Leptin and ghrelin. Leptin and ghrelin regulate food intake and their functions in obese people have been intensively studied. We offer monoclonal antibodies against leptin and ghrelin for research purposes.
Cat.# Product name
2AN6 Human adiponectin, antibody
4HA1 Glycated hemoglobin HbA1c, antibody
4HH0 Hemoglobin human HbA10, antibody
2P9 Human proinsulin, antibody
2I1 Human insulin, antibody
2LE1 Human leptin, antibody
Cat.# Product name
8AN7 Adiponectin, human, native
Adiponectin TechNotes
HbA1c TechNotes
Rat C-peptide and insulin Technotes
Kogan AE, et al. (2013) Oligomeric adiponectin forms and their complexes in the blood of healthy donors and patients with type 2 diabetes mellitus. J Immunoassay Immunochem 34(2): 180-196. doi: 10.1080/15321819.2012.699494
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