New generation of high sensitivity cTnI antibodies TechNotes

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New generation of high sensitivity cTnI antibodies TechNotes

HyTest presents a new generation of high sensitivity anti-cardiac troponin I (anti-cTnI) monoclonal antibodies (MAbs). These antibodies were specially designed for our customers who look for the antibodies specific to the fragment 13-36 (13PAPAPIRRRSSNYRAYATEPHAKK36) of the cTnI molecule to be used for the development of high sensitivity cTnI assays.
These new MAbs are specific to the different epitopes located within the fragment 13-36 of cTnI. This fragment has a sequence unique for the cardiac isoform of troponin I, thus the MAbs are not cross-reacting with the two skeletal isoforms of TnI (skTnI). Also this fragment is distant from the site of cTnI -TnC interaction and that is why these new antibodies recognize the free cTnI and cTnI complexed with TnC with the same efficiency.

References:
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